Arak University Cell and Tissue Journal 2228-7035 5 1 2014 07 01 Inducing Effect of Aloe Vera Gel Extract on Epithelial Growth Factor Receptor Gene Expression in Cutaneous Wounds of Male Mice Balb/c Inducing Effect of Aloe Vera Gel Extract on Epithelial Growth Factor Receptor Gene Expression in Cutaneous Wounds of Male Mice Balb/c 53 61 6525 10.52547/JCT.5.1.53 FA N N M A H J Journal Article 2014 07 06 Aim: Present study was done to assess the effects of Av gel on some molecular aspects in wound healing process of mouse damaged skin. <br />Material and Methods: 36 Male mice <em>balb/c </em>were used. Animals were divided into 3 groups; negative control (without wound), sham-operated (wound treated with physiological serum) and experimental (wound treated with Av gel extract). In each group, two equal full-thickness wounds were made on the mice back sides. Experimental group received daily a dose of Av gel extract on the top of wound sites (without bandage) for a period of 16 days. On 8^th and 16^th post wounding day, for the purpose of EGF receptor gene expression evaluation and lipid peroxidation (LPO) , skin and blood serum sampling were done respectively  and data were analyzed by Repeated measures ANOVA at significant level p < 0.05 <br />Results: Av gel extract treatments increased EGF receptor gene expression in the wound area. Wound healing percentage was also increased in experimental groups compared to sham group. It was also found that the amount of LPO end-product in blood sera was reduced to Av treated mice in the end of test. <br />Conclusion: Av gel extract can induce EGF receptor gene expression in mice damaged skin, and play a pivotal role in wound healing process. Aim: Present study was done to assess the effects of Av gel on some molecular aspects in wound healing process of mouse damaged skin. <br />Material and Methods: 36 Male mice <em>balb/c </em>were used. Animals were divided into 3 groups; negative control (without wound), sham-operated (wound treated with physiological serum) and experimental (wound treated with Av gel extract). In each group, two equal full-thickness wounds were made on the mice back sides. Experimental group received daily a dose of Av gel extract on the top of wound sites (without bandage) for a period of 16 days. On 8^th and 16^th post wounding day, for the purpose of EGF receptor gene expression evaluation and lipid peroxidation (LPO) , skin and blood serum sampling were done respectively  and data were analyzed by Repeated measures ANOVA at significant level p < 0.05 <br />Results: Av gel extract treatments increased EGF receptor gene expression in the wound area. Wound healing percentage was also increased in experimental groups compared to sham group. It was also found that the amount of LPO end-product in blood sera was reduced to Av treated mice in the end of test. <br />Conclusion: Av gel extract can induce EGF receptor gene expression in mice damaged skin, and play a pivotal role in wound healing process. https://jct.araku.ac.ir/article_6525_82356b37a12462391abf004c8362d389.pdf