Arak University Cell and Tissue Journal 2228-7035 11 4 2021 02 19 Morphological changes in lung tissue following the uptake of silver nanoparticles produced by biosynthesis in trained male Wistar rats Morphological changes in lung tissue following the uptake of silver nanoparticles produced by biosynthesis in trained male Wistar rats 262 274 243045 10.52547/JCT.11.4.262 FA F Pourmand Department of Exercise Physiology, Faculty of Basic Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran SJ Ziaolhagh Department of Exercise Physiology, Faculty of Basic Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran S Molzemi Department of Laboratory Sciences, School of Medical Science, Shahroud Branch, Islamic Azad University, Shahroud, Iran. Journal Article 2021 03 16 <strong>Aim:</strong> Therefore, this study aimed to investigate the amount of lung tissue damage in trained rats due to biological silver nanoparticles.<br /><strong>Material and Methods:</strong> 30 male rats were divided into 6 groups of healthy control, nano-silver, aerobic training, anaerobic training, nano-silver + aerobic training, nano-silver + anaerobic training. First, the training groups trained with the aerobic and anaerobic protocol for 10 weeks. Then, intraperitoneal injection of silver nanoparticles was injected 5 times per 10% of the  bodyweight of each rat, and 48 hours after the last injection, the rats were anesthetized and sampled. The samples were photographed and studied by hematoxylin-eosin staining with a light microscope.<br /><strong>Results:</strong> The results showed that anaerobic exercise was significantly effective in weight loss in rats (p = 0.045). Also, oxygen consumption increased in all groups except the group receiving nano-silver compared to the control group (p = 0.000). Injection of biological nano-silver also caused inflammation and hyperemia in the lung tissue of untrained rats. However, in the anaerobic training group, inflammation and hyperemia were less than in the aerobic group.<br /><strong>Conclusion:</strong> It seems that injection of biologically produced silver nanoparticles causes structural complications in the lung tissue of male Wistar rats. Also, the results of the present study showed that anaerobic pre-conditioning is more beneficial than aerobic in reducing these effects.<br /><strong> </strong> <strong>Aim:</strong> Therefore, this study aimed to investigate the amount of lung tissue damage in trained rats due to biological silver nanoparticles.<br /><strong>Material and Methods:</strong> 30 male rats were divided into 6 groups of healthy control, nano-silver, aerobic training, anaerobic training, nano-silver + aerobic training, nano-silver + anaerobic training. First, the training groups trained with the aerobic and anaerobic protocol for 10 weeks. Then, intraperitoneal injection of silver nanoparticles was injected 5 times per 10% of the  bodyweight of each rat, and 48 hours after the last injection, the rats were anesthetized and sampled. The samples were photographed and studied by hematoxylin-eosin staining with a light microscope.<br /><strong>Results:</strong> The results showed that anaerobic exercise was significantly effective in weight loss in rats (p = 0.045). Also, oxygen consumption increased in all groups except the group receiving nano-silver compared to the control group (p = 0.000). Injection of biological nano-silver also caused inflammation and hyperemia in the lung tissue of untrained rats. However, in the anaerobic training group, inflammation and hyperemia were less than in the aerobic group.<br /><strong>Conclusion:</strong> It seems that injection of biologically produced silver nanoparticles causes structural complications in the lung tissue of male Wistar rats. Also, the results of the present study showed that anaerobic pre-conditioning is more beneficial than aerobic in reducing these effects.<br /><strong> </strong> https://jct.araku.ac.ir/article_243045_18d0a4811765c32562a86c2d5ca69a19.pdf