Cell and Tissue Journal

Abstract Aim: The aim of this study was to ciprofloxacin labeling by technetium^99m and its bio distribution in normal and infected laboratory animals for the site of infection detection. 
Material and Methods: labeling of ciprofloxacin by ^99mTecnhetium at best concentration (2mg) and tin chloride at 50-600 micrograms concentration at different temperatures as well as pH using thin layer chromatography and different solvents were evaluated. Heart, lung, stomach, intestine, kidney, blood, spleen and muscle tissues separated and counted by HPGe.                                                                                                                            
Results: Radiochemical purity found to be not less than 90% and serum stability was the same at least for 1hr bio distribution studies showed the muscle at 1 and 4 hrs. Were observed after injection.                                                                                   
Conclusion: Ciprofloxacin labeling by direct method in high radiochemical purity may be used as a formulated compound for the site of infection diagnosis in experimental animals.