Effects of Rosa canina fruit hydroalcoholic extract on lipid profile and liver enzymes level in diabetic mice
Volume 10, Issue 1, Spring 2019, Pages 34-41
https://doi.org/10.52547/JCT.10.1.34
S Sadigh-Eteghad, F Rahimi, J Mahmoudi, L Baradaran
Abstract Aim: This study was aimed to investigate the effects of Rosa canina (RC) fruit hydroalcoholic extract on lipid profile and liver anzymes level in diabetic mice.
Material and Methods: Ninty-six male mice were divided into 4 groups. The normal and diabetic groups received normal saline (p.o., 0.5 ml), however RC and RC-treated diabetic groups received RC hydroalcoholic extract (p.o., 500 mg/kg). Diabetes was induced by a single dose of streptozotocin (STZ) (i.p., 200 mg/kg) and 10, 20, and 30 dayes after diabetes induction the lipd profile (cholesterol, triglyceride, LDL, HDL and VLDL) and liver anzymes (ALP, ALT and AST) were evaluated.
Results: Glucose level in the diabetic groups significantly(p < 0.01) increased compared with the control group. Administration of the extract in the diabetic group resulted in significant reduction(p < 0.01) in LDL, VLDL, triglyceride and cholesterol levels in comparison with diabetic animals. Administration of the extract in the diabetic group significantly increased (p < 0.05) HDL level and decreased (p < 0.01) ALT and AST levels.
Conclusion: RC fruit extract has the regulatory role in controlling lipid profile and liver anzymes level in mice models of diabetes.