The protective effects of quercetin against malathion- induced oxidative stress and myocardial damage in in Wistar male rats
Volume 10, Issue 2, Autumn 2019, Pages 63-71
https://doi.org/10.52547/JCT.10.2.63
R Yousefi, H Hatami Nemati, F Shahbazi, AR Ali hemati, H Ahmadi
Abstract -
Aim: The purpose of this study was to investigate the protective effects of quercetin on myocardial tissue damage in male Wistar rats during malathion poisoning.
Material and Methods: This study was performed on seven groups of six male rats. After 24 hours of intraperitoneal injection of quercetin, Malathion or a combination of these drugs, the heart of the animals was separated, and tissue slice was prepared. After tissue homogenization, oxidative stress parameters were measured in this area.
Results: Intraperitoneal injection of 200 mg/kg of malathion significantly induced lipid peroxidation (p < 0.01) and oxidative stress (p < 0.001) as well as necrosis and inflammation in myocardial tissue. However, intra-peritoneal injection of quercetin (50mg/kg) reduced malathion-induced toxicity on lipid peroxidation (p < 0.001), oxidative stress (p < 0.05), as well as inflammation and myocardial tissue damage.
Conclusion: The results suggest that quercetin is able to improve myocardial tissue damage and restore the rate of oxidative stress in malathion-treated groups to normal levels.