Evaluation of the protective effects of Stachys lavandulifoliaVahl. on ethanol induced testicular damages in Wistarrats
Volume 9, Issue 4, Winter 2019, Pages 310-320
https://doi.org/10.52547/JCT.9.4.310
S Yari, R Karamian, AH Asadbegy, M Asadbegy, M Rajabi
Abstract Aim: This study was aimed to examine the effects of Stachys lavandulifolia extract (SL) on ethanol-induced testicular damages.
Material and methods: In the current study, 24 male Wistar rats were divided into 4 groups: control, ethanol (5 g kg -10) and ethanol (5 g kg -1) + SL (500 mg kg-1) group and SL (500 mg kg-1). After the treatment for 4 weeks, mean seminiferous tubule diameter (MSTD) and Johnsen’s mean testicular biopsy score (MTBS) criteria were used for histological evaluation. In addition, sperm parameters including sperm count and motility were analyzed.
Results: Our data indicate that ethanol administration caused a significant decrease in the sperm count and motility in the ethanol group but SL ameliorated this reduction in SL + ethanol group. Moreover, both MSTD and MTBS values were decreased in the ethanol-treated rats. However, administration of ethanol together with SL resulted in significant improvements in both of these values.
Conclusion: In conclusion, our study revealed that the reproductive toxicity was caused by ethanol may be prevented by SL treatment