Evaluation of Curcuma longa L. and bovine ghee effects on experimental stomach ulcers healing in rat
Volume 6, Issue 2, Summer 2015, Pages 123-134
https://doi.org/10.52547/JCT.6.2.123
SE S, Sh E, N M, M F, S N, H R
Abstract Aim: This study was done to evaluate the therapeutic effects of Curcuma longa L. rhizome powder and bovine ghee mixture on experimental stomach ulcers in rat.
Material and methods: Stomach ulcer induction was done in 48 food deprived male rats (250-300 gr) using orally Indomethacin (50 mg/kg suspended in 1% carboxymethyl cellulose. Animals divided randomly into five groups. The normal and untreated (Indomethacin) group just received normal saline. The treated groups received different doses of C. longa and bovine ghee (500 and 750 mg C. longa in 10 ml ghee/per kg) for three successive days. On the third day, the rats were killed and their stomachs were removed for histological studies. Stomach ulcers number and length were measured and also ulcer index was calculated.
Results: Results showed that the mixture of C. longa and bovine ghee is significantly caused decreasing gastric ulcer index, inflammatory cells, blood capillaries densities (p < 0.001) and increasing mucosal layer thickness (p < 0.001) and secreted mucus (p < 0.05) in treated groups in comparison with untreated group.
Conclusion: According to the results, the mixture of C. longa and bovine ghee is significantly accelerated healing of experimental stomach ulcers.