Histomorphometric study effect of alcoholic extract of grape seed (Vitis Vinifera) on wound healing diabetic male Wistar rats
Volume 7, Issue 3, Winter 2017, Pages 293-300
https://doi.org/10.52547/JCT.7.3.293
F Alah gahi, A Shiravi, V Hojati
Abstract Aim: In the present investigation, the effects of grape seed (Vitis Vinifera) alcoholic extract were examined on skin Histomorphometric wound healing changes in diabetic Wistar rats.
Material and methods: forty eight male wistar rats were divided into four groups: negative control, positive control, the first experimental and the second experimental. In all of treated rats, a scar in the length of three centimeter was created on the left of the vertebral column. The wound healing was evaluated microscopic as well as macroscopic. The methods Mann – Whitney, Kruskal – Wallis were used for data analyses. The used software was SPSS ver. 16.
Results: agglutination in diabetic groups was longer than normal, while the process in the group treated with V. vinifera was quicker than the control and also first experimental groups, respectively.
Conclusions: the obtained results showed that V. vinifera ointment accelerate the wound healing in normal and diabetic samples.