Morphological changes in lung tissue following the uptake of silver nanoparticles produced by biosynthesis in trained male Wistar rats
Volume 11, Issue 4, Winter 2021, Pages 262-274
https://doi.org/10.52547/JCT.11.4.262
F Pourmand, SJ Ziaolhagh, S Molzemi
Abstract Aim: Therefore, this study aimed to investigate the amount of lung tissue damage in trained rats due to biological silver nanoparticles.
Material and Methods: 30 male rats were divided into 6 groups of healthy control, nano-silver, aerobic training, anaerobic training, nano-silver + aerobic training, nano-silver + anaerobic training. First, the training groups trained with the aerobic and anaerobic protocol for 10 weeks. Then, intraperitoneal injection of silver nanoparticles was injected 5 times per 10% of the bodyweight of each rat, and 48 hours after the last injection, the rats were anesthetized and sampled. The samples were photographed and studied by hematoxylin-eosin staining with a light microscope.
Results: The results showed that anaerobic exercise was significantly effective in weight loss in rats (p = 0.045). Also, oxygen consumption increased in all groups except the group receiving nano-silver compared to the control group (p = 0.000). Injection of biological nano-silver also caused inflammation and hyperemia in the lung tissue of untrained rats. However, in the anaerobic training group, inflammation and hyperemia were less than in the aerobic group.
Conclusion: It seems that injection of biologically produced silver nanoparticles causes structural complications in the lung tissue of male Wistar rats. Also, the results of the present study showed that anaerobic pre-conditioning is more beneficial than aerobic in reducing these effects.