ZnO Nanoparticles Effects on Male Rat Gonad Histology and Its Effect on Blood Serum Sex Factors
Volume 6, Issue 2, Summer 2015, Pages 187-194
https://doi.org/10.52547/JCT.6.2.187
R F, S H, A A
Abstract Aim: In this study zinc oxide nanoparticles (ZnO nanoparticles) toxicity effects on some male sexual hormone levels in blood serum and testicular tissue in adult intact rats was studied.
Material and Methods: The rats were divided into a control and four treatment groups. ZnO nanoparticles at concentrations of 2.5 and 1 g/kg were orally administered for two treated groups and intra-peritoneal were synchronic used for two other treated groups. Nanoparticles effect and its damages on testicular tissue were studied one, seven and fourteen days after treatment.
Results: Blood serum tests showed that serum LH and FSH levels increased in zinc oxide nanoparticles treated groups in comparison with control (p < /em><0.05). Also, testes tissue slides examination showed specific tissue damages in all four zinc oxide nanoparticles treated groups in comparing to control. These injuries represent irregularities in the cell layers, cell-free seminiferous tubules, congestion in seminiferous tubules area and changes in spermatogene cell nucleus.
Conclusion: Results of the present study show nanoparticle zinc oxide effect on morphological structure and sex hormones.