Volume 12 (2021)
Volume 11 (2020)
Volume 10 (2019)
Volume 9 (2018)
Volume 8 (2017)
Volume 7 (2016)
Volume 6 (2015)
Volume 5 (2014)
Volume 4 (2013)
Volume 3 (2012)
Volume 2 (2011)
Volume 1 (2011)
Research - Scientific
Structural, cellular and molecular mechanisms involved in the Epithelial-to-Mesenchymal Transition in Cancer

S Moniri Javadhesari; Vaezi Heris H

Volume 13, Issue 2 , August 2022, Pages 71-94

https://doi.org/10.52547/JCT.13.2.71

Abstract
  Intoduction: Cancer as one of the most common genetic diseases is the leading cause of death worldwide. Cancer cells undergo various genetic and phenotypic changes to spread and survive. In the early stages, these changes lead to the development of tumor, while at the advanced stages they can provide ...  Read More

Research - Scientific
The effect of regular exercise training on gene expression of Autophagy related protein 5 (ATG5) and Autophagy related protein 7 (ATG7) of white adipose tissue of mice with a high-fat diet

S Daneshyar; A Khosravi; F OmidAli; S Shokati Basir

Volume 13, Issue 2 , August 2022, Pages 95-106

https://doi.org/10.52547/JCT.13.2.95

Abstract
  Aim: Previous studies have shown that Autophagy (lysosome-dependent self-degradation) is upregulated in white adipose tissue of obese subjects. Autophagy-related proteins i.e ATG5 and ATG7 play an essential role in the early stage of the autophagic process. On the other hand, it was found that exercise ...  Read More

Research - Scientific
The effect of lovastatin on cell proliferation and neurotrophic factor expression of bone marrow mesenchymal stem cells in vitro

bageri A; MT Ghorbanian; A Kosha

Volume 13, Issue 2 , August 2022, Pages 107-120

https://doi.org/10.52547/JCT.13.2.107

Abstract
  Aim: In recent years using of Bone marrow mesenchymal stem cells (BMSC) in regenerative medicine, tissue engineering and gene therapy is highly regarded. Convenient access, ability to expand and MSC differentiation capacity along with the ability of adhesion to plastic surfaces and in-vitro growth and ...  Read More

Research - Scientific
The comparative study of growth and drug response of MCF-7 and MDA-MB231 human breast cancer cells in two- and three-dimensional culture

E Sefidgar; SH Akbari-Birgani

Volume 13, Issue 2 , August 2022, Pages 121-134

https://doi.org/10.52547/JCT.13.2.121

Abstract
  Aim: The three-dimensional (3D) culture of cancer cells is a method that provides the possibility for growth and comprehensive communication of cells in a 3D space, leading to the generation of tumorspheres. In recent years, developing tumor models from cancer cells by using the 3D cell culture method ...  Read More

Research - Scientific
Silymarin Effects on Ovine Fetal Bone Marrow-Derived Mesenchymal Stem Cells Differentiation into Osteogenic Lineage

I Morovati; T Mohammadi; M Pooyanmehr; L Soltani

Volume 13, Issue 2 , August 2022, Pages 135-150

https://doi.org/10.52547/JCT.13.2.135

Abstract
  Aim: Cell therapy using mesenchymal stem cells (MSCs) can be a promising tool in regenerative medicine. One of the richest sources of mesenchymal stem cells is fetal bone marrow. Silymarin has strong antioxidant and anti-inflammatory activities with a positive effect on the proliferation of some cells ...  Read More

Research - Scientific
Evaluation of siRNA Effects on Expression Levels of snail and miR143 in Metastatic Breast Cancer Cells

M Sattarivand; R Mohammadzadeh

Volume 13, Issue 2 , August 2022, Pages 151-166

https://doi.org/10.52547/JCT.13.2.151

Abstract
  Aim: In the past decades, many efforts have been made with the aim of searching for new tools to treat cancer. In this regard, the discovery, investigation and application of techniques related to small interfering RNAs (siRNA) has been one of the most significant advances in the field of cancer detection ...  Read More