Volume 13 (2022)
Volume 12 (2021)
Volume 11 (2020)
Volume 10 (2019)
Volume 9 (2018)
Volume 8 (2017)
Volume 7 (2016)
Volume 6 (2015)
Volume 5 (2014)
Volume 4 (2013)
Volume 3 (2012)
Volume 2 (2011)
Volume 1 (2011)
A study on the effect of Tamarindus indica kernel extracts on viability, proliferation, and induction of apoptosis in human ‌prostate cancer (LNCaP), colon cancer (HT-29), and fibroblast cell lines

M Pourali; MM Yaghoobi

Volume 13, Issue 1 , January 2022, , Pages 11-22

https://doi.org/10.52547/JCT.13.1.11

Abstract
  Aim: Cancer is one of the leading causes of death worldwide, and its treatment is always associated with side effects such as drug resistance. So, there is a strong tendency for the identification of new herbal anti-cancer compounds.Material and Methods: In this study, a range of 0.5-12 µg/mL of ...  Read More

Induction of Apoptosis in Human Cancer A549 Cells Through Hydroalcoholic Extract of Salvia officinalis

E Hoveizi; F Pouratar; M Kesmati; A Shahriari

Volume 11, Issue 2 , September 2020, , Pages 100-112

https://doi.org/10.52547/JCT.11.2.100

Abstract
  Aim: The purpose of the current study is to investigate the cytotoxic and oxidative effects of Salvia officinalis hydroalcoholic extract on cancer A549 cells. Material and Methods: The cells were seeded in plates to investigate concentrations of Salvia officinalis extract and MTT measurement was done ...  Read More

Comparison of Achillea wilhelmsii, Silybum marianumseed, Echinacea purpurea, Adiantum capillus-veneris and apricot kernel extracts effects on the proliferation and apoptosis of breast cancer cells

L Soltani; M Darbemamieh

Volume 11, Issue 1 , August 2020, , Pages 73-86

https://doi.org/10.52547/JCT.11.1.73

Abstract
  Aim: The aim of this study was to compare the anti-proliferative and apoptotic effects of hydroalcoholic extracts of different herbal medicines (Achillea wilhelmsii, Silybum marianumseed, Echinacea purpurea, Adiantum capillus-venerisand apricot kernel) against breast cancer cells (Mcf-7). Material and ...  Read More

Anticancer activity of Blepharis persica seed hydroalcoholic extract on (MCF-7) human breast cancer and (LNCaP) prostate cancer cell lines and its synergistic effect with doxorubicin

K Aghaabbasi; H Hassani Kumleh; N Askari; M Torkzadeh-Mahani; A ramzani-ghara

Volume 9, Issue 3 , February 2019, , Pages 206-221

https://doi.org/10.52547/JCT.9.3.206

Abstract
  Aims: This study was aimed to investigate the anti-proliferative effects of hydroalcoholic extract of Blepharis persica seed and its synergy effect with doxorubicin on human breast cancer and prostate cancer cell lines. Materials and Methods: hydroalcoholic extract of  seed was prepared using maceration, ...  Read More

The synthesis of albumin nanocarriers conjugated with a GSK3β inhibitor to investigate its effect on survival of breast cancer cell line MCF-7

M Mohammadian Namghi; A Parvaneh Tafreshi; Sh Abbasi Ahmadi

Volume 9, Issue 3 , February 2019, , Pages 292-309

https://doi.org/10.52547/JCT.9.3.292

Abstract
  Aim: 7-bromoindirubin-3'-oxime (7-BIO) is a well-known glycogen synthase kinase-3β (GSK3β) inhibitor with anticancer effects on different cancer cell lines. However, due to its low water solubility, absorption and high gastrointestinal toxicity, it has been inapplicable in clinics so far. In ...  Read More

Effect of silymarin and lithium chloride on DNA integrity in epidydimal ram sperm

T Choobineh; M Khodaei-Motlagh; HR Momeni; N Darbandi

Volume 9, Issue 1 , July 2018, , Pages 76-85

https://doi.org/10.52547/JCT.9.1.76

Abstract
  Aim: The aim of this study was to evaluate the effect of silymarin and lithium chloride on DNA integrity and nucleus of ram sperm. Material and Methods: In this study, Farahani's ram testes were obtained from Arak slaughterhouse immediately after ram daily slaughter and transferred to the research laboratory. ...  Read More

Cytotoxicity and apoptotic effect of oxaliplatin on colon cancer cell line (HT29) and analysis of caspase 3 and caspase 9 gene expression using Real Time PCR method

B Yonesi,; , A Mirzaie; E Aliasgari

Volume 8, Issue 4 , May 2018, , Pages 364-373

https://doi.org/10.52547/JCT.8.4.364

Abstract
  Aim: The aim of this study is investigation of cell toxicity of oxaliplatin on colon cancer cell line and analysis of caspase 3 and 9 apoptotic genes. Material and methods: In this experimental study, cytotoxicity of oxaliplatin on colon cancer cell line (HT29) was evaluated using MTT method in different ...  Read More

The viability, apoptosis rate and p75NTR gene expression in neural differentiation of adiposae derived stem cells in simulated microgravity

V Zarrinpour; Z Hajebrahimi; M Jaafarinia

Volume 8, Issue 2 , November 2017, , Pages 127-139

https://doi.org/10.52547/JCT.8.2.127

Abstract
  Aim: In this study, the effects of simulated microgravity on the apoptosis and expression of p75NTR gene were investigated in the adipose derived stem cells before and after the neural differentiation. Material and Methods: Human adipose derived stem cells were isolated, cultured and differentiated.  ...  Read More

Evaluation the antioxidant effect of crocin on neonate Balb/C mouse spermatogonial stem cells

A Shokri; J Baharara; E Amini

Volume 7, Issue 3 , January 2017, , Pages 219-229

https://doi.org/10.52547/JCT.7.3.219

Abstract
  Aim: The aim of this study is evaluating the effect of crocin as one of saffron bioactive compounds in mice spermatogenic stem cells. Material and Methods: Balb/c neonate spermatogenic stem cells were grown in DMEM-F12 medium and were treated with various concentrations of crocin (2.5, 5, 10, 20, 40 ...  Read More

Anti-cancerous effects of silver nanoparticles coated with curcmin on A2780 ovarian cancerous cells

T Ramezani; i M Nabiun; Baharar J; Parivar K; F Namvar

Volume 7, Issue 3 , January 2017, , Pages 313-322

https://doi.org/10.52547/JCT.7.3.313

Abstract
  Aim: In this study, the effects of curcumin- coated silver nanoparticles were examined on induction of apoptosis in ovarian cancer A2780 cell. Material and Methods: Silver nanoparticles coated with curcumin were biosynthesized, then A2780 cells were treated with different concentration of silver nanoparticles. ...  Read More

Study of the Effect of Bisphenol A on Viability, Morphological Changes and Induction of Apoptosis in Adult Rat Bone Marrow Mesenchymal Stem Cells

M SM; M M; AS A; B L

Volume 6, Issue 4 , February 2016, , Pages 513-522

https://doi.org/10.52547/JCT.6.4.513

Abstract
  Aim: This study aimed to investigate the effect of Bisphenol­ A on the cell viability, morphologic changes and induction of apoptosis in bone marrow mesenchymal stem cells of an adult rat. Material and Methods: The bone marrow mesenchymal stem cells were extracted using flashing-out method. At the ...  Read More

Study of side effects of busulfan on testis tissue and epididymal sperm of adult mice following treatment with clinical dose

P N; A V; MR T; S KH

Volume 6, Issue 4 , February 2016, , Pages 533-542

https://doi.org/10.52547/JCT.6.4.533

Abstract
  Aim: The aim of this study was to assess side effects of clinical dose of busulfan on testis and epididymal sperm of adult male mouse. Material and Methods: Male adult NMRI mice (25-35 g) were divided into two groups of sixteen each. Control and busulfan treated group were administered 100 μL DMSO ...  Read More

Effects of Time of Mild Oxidative Stress before Freezing on the Post-Thawed Sperm Quality

M Sh; M Zh; A Sh; M Sh; A N; A N

Volume 5, Issue 4 , March 2015, , Pages 401-408

https://doi.org/10.52547/JCT.5.4.401

Abstract
  Aim: The purpose of this study was to consider the effect of mild oxidative stress period on the frozen-thawed bull semen performance. Material and Methods: In this study, 120 minutes was considered for equilibration of sperm before freezing. One µm of Nitric Oxide (NO) at the 0, 45, 90 and 120 ...  Read More

Effect of Aluminum Toxicity on Inducing of Apoptosis in Cell Suspension of Rice (Oryza sativa) Khazar and Tarom Cultivars

A N; M M; M Y; MR A

Volume 5, Issue 1 , July 2014, , Pages 1-9

https://doi.org/10.52547/JCT.5.1.1

Abstract
  Aim: In this study the effect of AlCl3 toxicity on apoptosis in cells suspension of two rice cultivars Khazar, Tarom were investigated. Material and Methods: In present research cells suspension of two rice cultivars (Khazar and Tarom) grew up in liquid Murashig and Skoog medium within a period of 3 ...  Read More

Evaluation of Viability and Apoptosis in Human Sperm Treated with Sodium Arsenite
Volume 4, winter , March 2014, , Pages 361-370

https://doi.org/10.52547/JCT.4.4.361

Abstract
  Aim: The aim of this research was to evaluate viability as well as morphological and biochemical featears of apoptosis in human sperm treated with sodium arseinte. Material and methods: Human sperm samples were exposed with different concentration of sodium arsenite (0, 0.1, 20 and 100 µM) for ...  Read More

Induction of Differentiation and Cell Death of the Derivative of 4-aryl-4H-Chromenes Family on NB4 Human Promyelocytic Leukemia Cell Line
Volume 4, Issue 2 , October 2013, , Pages 139-147

https://doi.org/10.52547/JCT.4.2.139

Abstract
  Aim: Chromene derivatives are able to growth inhibition and induce apoptosis in different cell types. In this study, we reported a derivative of 4-aryl-4H-chromenes with differentiation and apoptotic activity against NB4, Acute Promyelocytic Leukemia (APL) cell. Matherial and Methods: The cells were ...  Read More

Determination of Apoptotic Doses of Bee Venom on Human Promyelocytic Leukemia Cells
Volume 2, Issue 4 , March 2012, , Pages 425-433

https://doi.org/10.52547/JCT.2.4.425

Abstract
  Aim: Recently, researchers have reported that BV (Bee Venom) has a potent anti inflammatory, anti tumor and anticancer effects. Besides, one of the essential aim in cancer therapy is restoring apoptosis. The Objective in this study was determination of apoptotic concentration induced by BV (Autumn, Semnan) ...  Read More

The inhibitory effect of calcium chelators on the apoptosis of motor neurons in cultured adult mouse spinal cord slices
Volume 1, Issue 1 , October 2011, , Pages 1-8

https://doi.org/10.52547/JCT.1.3.1

Abstract
  Aim: The aim of this study was to investigate the inhibitory effect of calcium chelators on apoptosis of motor neurons in adult spinal cord slices. Materials and Methods: The thoracic region of adult mouse spinal cord was sliced by a tissue chopper into 400 µm sections and divided into four groups: ...  Read More

Growth Inhibition and Induction of Apoptosis by Ether Soluble Metabolites of Streptomyces sp. ABRIINW 111 in Human Myeloid Leukemia K562 Cell Line
Volume 2, Issue 3 , October 2011, , Pages 225-234

https://doi.org/10.52547/JCT.2.3.225

Abstract
  Aim: Since induction of apoptosis is an important strategy in cancer treatment, many attempts are in program to find new apoptotic inducer agents. Hence, ether soluble metabolites from Iranian native bacteria, Streptomyces sp. ABRIINW 111, were isolated and anti-cancer activity of these metabolites was ...  Read More